Research performed at LSU Health New Orleans Neuroscience Center of Excellence reviews that Elovanoids, bioactive chemical messengers produced from omega-3 very-long-chain polyunsaturated fatty acids found by the Bazan lab in 2017, might block the virus that causes COVID-19 from getting into cells and defend the air cells (alveoli) of the lung. Their findings are revealed on-line in Scientific Reports.
“Because the compounds are protective against damage in the brain and retina of the eye and the COVID-19 virus clearly damages the lung, the experiment tested if the compounds would also protect the lung,” notes Nicolas Bazan, MD, PhD, Director of the LSU Health New Orleans Neuroscience Center and senior creator of the paper.
The analysis crew examined Elovanoids (ELVs) on contaminated lung tissue from a 78-year-old man in petri dish cultures. They discovered that ELVs not solely lowered the power of the SARS-CoV-2 spike protein to bind to receptors and enter cells, however additionally they triggered the manufacturing of protecting, anti-inflammatory proteins that counteract lung harm.
The scientists report that ELVs decreased the manufacturing of ACE2. ACE2 is a protein on the floor of many cell sorts. ACE2 receptors act like locks on cells, and the SARS-CoV-2 spike proteins act like keys that open the locks letting the virus enter cells to multiply quickly. They additionally demonstrated for the primary time that alveolar cells are endowed with pathways for the biosynthesis of ELVs.
“Since SARS-CoV-2 affects nasal mucosa, the GI tract, the eye, and the nervous system, uncovering the protective potential of ELVs expands the scope of our observations beyond the lung,” provides Dr. Bazan. “Our results provide a foundation for interventions to modify disease risk, progression, and protection of the lung from COVID-19 or other pathologies (including some types of pneumonia).”
The LSU Health New Orleans analysis crew included Drs. Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Marie-Audrey I. Kautzmann, Aram Asatryan, William C. Gordon, Khanh V. Do, Bokkyoo Jun, and Pranab Ok. Mukherjee, in addition to Dr. Nicholas J. Maness from Tulane University and Dr. Nicos A. Petasis from the University of Southern California.
This work was supported by an Institutional Grant from the LSU Health New Orleans School of Medicine.
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