In the tip, the examine staff discovered megakaryocytes within the brains of one-third of the deceased COVID-19 sufferers.
The findings had been revealed on-line Feb. 12 inJAMA Neurology.
So do megakaryocyte mind formations clarify COVID-19 mind fog? Nauen confused that it is untimely to characterize the discovering as proof of trigger and impact.
“Knowing they’re there is the first step. Now we need to figure out why they’re in the brain, and what’s signaling them to come to the brain by mistake, whether this very different kind of inflammation that we’ve never seen before is responsible for brain fog and may also be contributing to a heightened risk for stroke,” he famous.
“None of these patients had had strokes. And I’m speculating. But you can imagine that if you start to clot off, or block off, this very intricate network of carefully regulated capillaries, then your blood pressure is going to change, get higher, and perhaps raise the risk for stroke,” Nauen stated.
Meanwhile, Dr. Larry Goldstein, chairman of the division of neurology on the University of Kentucky and co-director of the Kentucky Neuroscience Institute, provided a cautious tackle Nauen’s findings.
“‘Brain fog’ is not a specific condition and has no defining diagnostic criteria,” Goldstein stated.
Brain fog can be “not specific to COVID, and can occur in association with a variety of inflammatory conditions, degenerative diseases, medications — particularly some cancer chemotherapies — and intensive care unit hospitalizations, among others,” he added.
Still, within the case of COVID-19, may megakaryocytes be the trigger? Goldstein acknowledged that the reason is “plausible.” But so are a wide selection of different explanations, together with irritation, diminished blood oxygen, stroke, diminished blood stream and/or “the general complications of hospitalization for an acute, life-threatening illness,” he stated.
So, absent mind scans or detailed reviews on every affected person’s “cognitive status,” it is unimaginable to know, Goldstein confused. That means, for now, all that may be stated is that “there are a variety of ways brain injury could occur in this setting.”
There’s extra on COVID-19 mind fog at NewYork-Presbyterian Hospital.
SOURCES: David Nauen, MD, PhD, assistant professor, division of pathology, Johns Hopkins University, Baltimore; Larry Goldstein, MD, chairman, division of neurology, and co-director, Kentucky Neuroscience Institute, University of Kentucky, Lexington; JAMA Neurology, Feb. 12, 2021, on-line