An earlier analysis on European inhabitants studied variations in a particular DNA section and located that trendy people inherited this DNA from Neanderthal which is strongly related to extreme COVID-19 infection and hospitalisation. The theory had recommended that the genome, answerable for extreme infection of Covid-19, is current in 50 % of South Asians and simply 16 % of Europeans.
In a current study, led by Director, Centre for DNA Fingerprinting and Diagnostics & Chief Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad Kumarasamy Thangaraj and Prof Gyaneshwer Chaubey of the Banaras Hindu University, Varanasi have concluded that the genetic variants answerable for COVID-19 severity amongst Europeans could not play a task in COVID-19 susceptibility amongst South Asians. This discovering has been printed within the journal Scientific Reports, printed by Nature, US.
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“In this study, we have compared infection and case fatality rates with South Asian genomic data over three different timelines during the pandemic. We have especially looked into a large number of populations from India and Bangladesh”, mentioned Thangaraj.
“Our result reiterates the unique genetic origin of South Asian populations and we suggest a dedicated genome-wide association study on South Asian COVID-19 patients is the need of the hour in the Asian sub-continent”, mentioned Prajjval Pratap Singh, first writer of this study.
“Due to the long term and complex genomic history of South Asia, it is likely that we’ll always experience a variable degree of susceptibility for any diseases. This study is consistent with our previous work on ACE2 gene which showed a strong genetic correlation with cases and case fatality rate in India in comparison to presence of ACE2 gene in Indian population”, mentioned Prof Chaubey of BHU.
The study additionally means that the genetic variants correlated with COVID-19 outcomes differ considerably amongst caste and tribal populations of Bangladesh.
“Scientists working in the area of population studies should be more cautious to interpret their findings by differentiating caste and tribal populations, more explicitly so in the Bangladeshi population”, mentioned Prof George van Driem a famend linguist and co-writer of the study.
“Apart from host genomics we should also focus on which variants are likely to escape the host defense of those already vaccinated”, mentioned Prof Anil Okay Tripathi, Director Institute of Science BHU.
Other contributors of this study embody: Anshika Srivastava and Nargis Khanam from BHU, Varanasi; Dr Abhishek Pathak and Prof Royana Singh, Institute of Medical Sciences, BHU; Dr Gazi Sultana from Dhaka University, Bangladesh; Dr Pankaj Shrivastava, Forensic Science Laboratory, Sagar, MP; and Dr Prashanth Suravanjhala, Birla Institute of Scientific Research, Jaipur.